Record Awaiting Appraisal

Zhelnov P. A critical appraisal of ‘Thomas R, Trapani D, Goodyer-Sait L, Tomkova M, Fernandez-Rozadilla C, Sahnane N, Woolley C, Davis H, Chegwidden L, Kriaucionis S, Maughan T, Leedham S, Palles C, Furlan D, Tomlinson I, Lewis A. The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression. Sci Rep. 2019 Sep 17;9(1):13463. doi: 10.1038/s41598-019-49952-x. PMID: 31530880; PMCID: PMC6748923’. Zheln. 2020 Dec 19;51(2):r1947d15. URI: https://zheln.com/record/2020/12/15/1947/.

Zheln Review Appraisal in 10 Steps:

1. ✅ Downloaded from the PubMed Systematic Subset Daily Updates
2. 🔄 Meets Shojania & Bero 2001 True Positive Criteria for Systematic Reviews by Either Title or Abstract?
3. 🔄 Full Text or Other Reports Collected by Zheln
4. 🔄 Generates Pragmatic Evidence Directly Relevant to Evidence-Based Practice?
5. 🔄 Is Duplicate?
6. 🔄 Passed or Failed Replication?
7. 🔄 Has Critical Conduct Flaws?
8. 🔄 Liked or Disliked by Zheln?
9. 🔄 Practical Implications Summarized by Zheln
10. 🔄 Appraisal Published & Call for Crowdfunding

I have uploaded this record from PubMed but haven’t appraised it yet.

If you want me to appraise this record, I’ve got several options for you:

• Wait until I get my hands on it myself.
• Buy a subscription on Patreon, GitHub Sponsors, or Open Collective for $1 to $600 and PM me with the review request.
• Send me $1 via PayPal with this reference in the message, and I’ll happily appraise it for you.
• Contact me by email or on Twitter, Facebook, Instagram, or Telegram, and I’m sure we’ll find a way around.