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Record #1538 on
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Zhelnov P. A critical appraisal of ‘Paracha N, Reyes A, Diéras V, Krop I, Pivot X, Urruticoechea A. Evaluating the clinical effectiveness and safety of various HER2-targeted regimens after prior taxane/trastuzumab in patients with previously treated, unresectable, or metastatic HER2-positive breast cancer: a systematic review and network meta- analysis. Breast Cancer Res Treat. 2020 Apr;180(3):597-609. doi: 10.1007/s10549-020-05577-7. Epub 2020 Feb 25. PMID: 32100144; PMCID: PMC7103014’. Zheln. 2020 Dec 19;51(2):r1538d15. URI:

Zheln Review Appraisal in 10 Steps:

  1. ✅ Downloaded from the PubMed Systematic Subset Daily Updates
  2. 🔄 Meets Shojania & Bero 2001 True Positive Criteria for Systematic Reviews by Either Title or Abstract?
  3. 🔄 Full Text or Other Reports Collected by Zheln
  4. 🔄 Generates Pragmatic Evidence Directly Relevant to Evidence-Based Practice?
  5. 🔄 Is Duplicate?
  6. 🔄 Passed or Failed Replication?
  7. 🔄 Has Critical Conduct Flaws?
  8. 🔄 Liked or Disliked by Zheln?
  9. 🔄 Practical Implications Summarized by Zheln
  10. 🔄 Appraisal Published & Call for Crowdfunding

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