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Zhelnov P. A critical appraisal of ‘Nourelden AZ, Elshanbary AA, El-Sherif L, Benmelouka AY, Rohim HI, Helmy SK, Sayed MK, Ismail A, Ali AS, Ragab KM, Zaazouee MS. Safety and Efficacy of Teplizumab for Treatment of Type One Diabetes Mellitus: A Systematic Review and Meta-analysis. Endocr Metab Immune Disord Drug Targets. 2020 Dec 9. doi: 10.2174/1871530320999201209222921. Epub ahead of print. PMID: 33302842’. Zheln. 2020 Dec 16;51(1):r181d12. URI:

Zheln Review Appraisal in 10 Steps:

  1. ✅ Downloaded from the PubMed Systematic Subset Daily Updates
  2. 🔄 Meets Shojania & Bero 2001 True Positive Criteria for Systematic Reviews by Either Title or Abstract?
  3. 🔄 Full Text or Other Reports Collected by Zheln
  4. 🔄 Generates Pragmatic Evidence Directly Relevant to Evidence-Based Practice?
  5. 🔄 Is Duplicate?
  6. 🔄 Passed or Failed Replication?
  7. 🔄 Has Critical Conduct Flaws?
  8. 🔄 Liked or Disliked by Zheln?
  9. 🔄 Practical Implications Summarized by Zheln
  10. 🔄 Appraisal Published & Call for Crowdfunding

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