Record Awaiting Appraisal

Zhelnov P. A critical appraisal of ‘Scheinberg T, Kench J, Stockler M, Mahon KL, Sebastian L, Stricker P, Joshua AM, Woo H, Thanigasalam R, Ahmadi N, Centenera MM, Butler LM, Horvath LG. Pharmacodynamics effects of CDK4/6 inhibitor LEE011 (ribociclib) in high-risk, localised prostate cancer: a study protocol for a randomised controlled phase II trial (LEEP study: LEE011 in high-risk, localised Prostate cancer). BMJ Open. 2020 Jan 26;10(1):e033667. doi: 10.1136/bmjopen-2019-033667. PMID: 31988233; PMCID: PMC7045211’. Zheln. 2020 Nov 18;47(1):r458d16. URI: https://zheln.com/record/2020/11/16/458/.

Zheln Review Appraisal in 10 Steps:

1. ✅ Downloaded from the PubMed Systematic Subset Daily Updates
2. 🔄 Meets Shojania & Bero 2001 True Positive Criteria for Systematic Reviews by Either Title or Abstract?
3. 🔄 Full Text or Other Reports Collected by Zheln
4. 🔄 Generates Pragmatic Evidence Directly Relevant to Evidence-Based Practice?
5. 🔄 Is Duplicate?
6. 🔄 Passed or Failed Replication?
7. 🔄 Has Critical Conduct Flaws?
8. 🔄 Liked or Disliked by Zheln?
9. 🔄 Practical Implications Summarized by Zheln
10. 🔄 Appraisal Published & Call for Crowdfunding

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