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Zhelnov P. A critical appraisal of ‘Thomalla G, Boutitie F, Ma H, Koga M, Ringleb P, Schwamm LH, Wu O, Bendszus M, Bladin CF, Campbell BCV, Cheng B, Churilov L, Ebinger M, Endres M, Fiebach JB, Fukuda-Doi M, Inoue M, Kleinig TJ, Latour LL, Lemmens R, Levi CR, Leys D, Miwa K, Molina CA, Muir KW, Nighoghossian N, Parsons MW, Pedraza S, Schellinger PD, Schwab S, Simonsen CZ, Song SS, Thijs V, Toni D, Hsu CY, Wahlgren N, Yamamoto H, Yassi N, Yoshimura S, Warach S, Hacke W, Toyoda K, Donnan GA, Davis SM, Gerloff C; Evaluation of unknown Onset Stroke thrombolysis trials (EOS) investigators. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Lancet. 2020 Nov 6:S0140-6736(20)32163-2. doi: 10.1016/S0140-6736(20)32163-2. Epub ahead of print. PMID: 33176180’. Zheln. 2020 Nov 14;46(2):r230d12. URI: https://zheln.com/record/2020/11/12/230/.

Zheln Review Appraisal in 10 Steps:

  1. ✅ Downloaded from the PubMed Systematic Subset Daily Updates
  2. 🔄 Meets Shojania & Bero 2001 True Positive Criteria for Systematic Reviews by Either Title or Abstract?
  3. 🔄 Full Text or Other Reports Collected by Zheln
  4. 🔄 Generates Pragmatic Evidence Directly Relevant to Evidence-Based Practice?
  5. 🔄 Is Duplicate?
  6. 🔄 Passed or Failed Replication?
  7. 🔄 Has Critical Conduct Flaws?
  8. 🔄 Liked or Disliked by Zheln?
  9. 🔄 Practical Implications Summarized by Zheln
  10. 🔄 Appraisal Published & Call for Crowdfunding

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