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Zhelnov P. A critical appraisal of ‘Imani MM, Golchin N, Safaei M, Rezaei F, Abbasi H, Sadeghi M, Lopez-Jornet P, Mozaffari HR, Sharifi R. Methylenetetrahydrofolate reductase C677T polymorphism is not associated with the risk of nonsyndromic cleft lip/palate: An updated meta-analysis. Sci Rep. 2020 Jan 30;10(1):1531. doi: 10.1038/s41598-020-58357-0. PMID: 32001764; PMCID: PMC6992667’. Zheln. 2020 Nov 14;46(2):r415d10. URI:

Zheln Review Appraisal in 10 Steps:

  1. ✅ Downloaded from the PubMed Systematic Subset Daily Updates
  2. 🔄 Meets Shojania & Bero 2001 True Positive Criteria for Systematic Reviews by Either Title or Abstract?
  3. 🔄 Full Text or Other Reports Collected by Zheln
  4. 🔄 Generates Pragmatic Evidence Directly Relevant to Evidence-Based Practice?
  5. 🔄 Is Duplicate?
  6. 🔄 Passed or Failed Replication?
  7. 🔄 Has Critical Conduct Flaws?
  8. 🔄 Liked or Disliked by Zheln?
  9. 🔄 Practical Implications Summarized by Zheln
  10. 🔄 Appraisal Published & Call for Crowdfunding

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